Thursday, April 30, 2009

Thursday April 30, 2009


Q: What is the half life of Argatroban?


Answer:
About 50 minutes

As Argatroban is metabolized in the liver, assuming patient has a normal liver function, its half life is about 50 minutes. It is monitored by PTT in same way as heparin drip.


In contrast, lepirudin, another direct thrombin inhibitor is primarily cleared by kidneys and should be either avoided or adjusted with renal insufficiency.

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