Sunday April 26, 2009

Q; Thrombotic thrombocytopenic purpura (TTP) is an occasional but serious side effect of PLAVIX® (clopidogrel bisulfate). Why its important to quickly recognize this side effect?


Answer: Its very important to recognise Clopidogrel associated TTP. It usually occurs within 2 weeks of start of treatment. Beside discontinuation of drug, total plasma exchange (TPE) should be initiated as soon as possible.

Persons who received plasma exchange within 3 days of TTP onset were more likely to survive than those in whom plasma exchange was initiated after 3 days (survival rate, 100% versus 27.3%)



Reference: click to get article

Clopidogrel-Associated TTP - Stroke. 2004;35:533.